Related Experiment Video
Updated: Jan 31, 2026

07:59
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
Published on: September 3, 2021
7.1K
Obstructing left sided colorectal cancer. A retrospective single Center study
Annali Italiani Di Chirurgia
|December 21, 2018
Summary
For elderly patients with left-sided obstructing colorectal cancer, primary resection with anastomosis is best for low-risk cases. Hartmann's procedure is recommended for high-risk patients or when the situation is uncertain.
Area of Science:
- Colorectal Surgery
- Surgical Oncology
- Geriatric Medicine
Background:
- Increasing incidence of colorectal cancer with severe occlusion symptoms in aging populations.
- Approximately 75% of malignant colorectal obstructions occur distal to the splenic flexure.
- Left-sided colorectal carcinoma presents unique management challenges, particularly in elderly patients.
Purpose of the Study:
- To evaluate the optimal surgical therapeutic strategy for left-sided colorectal carcinoma in patients over 65 years old.
- To compare the efficacy of different surgical approaches regarding postoperative morbidity, mortality, and long-term survival.
- To address the controversy surrounding the management of left-sided obstructing colorectal carcinoma in the elderly.
Main Methods:
- Literature review of surgical management strategies for left-sided obstructing colorectal carcinoma.
- Evaluation of patient age, emergency condition, and postoperative outcomes (morbidity, mortality, 5-year survival).
- Comparison of primary anastomosis with intraoperative colonic wash-out versus Hartmann's procedure.
Main Results:
- Management of left-sided obstructing colorectal carcinoma is debated.
- Hartmann's procedure is identified as a suitable choice for elderly patients.
- Resection with intraoperative colonic wash-out and primary anastomosis shows favorable outcomes in low-risk individuals.
Conclusions:
- Primary resection and anastomosis is the preferred strategy for low-risk patients with localized, resectable left-sided obstructing colorectal cancer without peritonitis.
- Hartmann's procedure is advised for high-risk patients or in cases with diagnostic uncertainty.
- The choice of surgical strategy should be individualized based on patient risk factors and disease characteristics.
Related Concept Videos
Lattice Centering and Coordination Number
11.6K
The structure of a crystalline solid, whether a metal or not, is best described by considering its simplest repeating unit, which is referred to as its unit cell. The unit cell consists of lattice points that represent the locations of atoms or ions. The entire structure then consists of this unit cell repeating in three dimensions. The three different types of unit cells present in the cubic lattice are illustrated in Figure 1.
Types of Unit Cells
Imagine taking a large number of identical...
Types of Unit Cells
Imagine taking a large number of identical...
11.6K
Center of Gravity
6.7K
The center of gravity (COG) of an object is the point where the object's total weight is considered to be concentrated. Knowing the location of the center of gravity is useful when predicting the behavior of a moving object or designing static structures. In a uniform gravitational field, the center of gravity is similar to the center of mass (COM); yet, these two points can be positioned differently. For example, the Moon's center of mass lies very close to its geometric center, but...
6.7K
Center of Gravity
2.2K
The center of gravity is the point at which an object's weight appears to be concentrated and can be used to balance the object perfectly. This point is essential in mechanics as it provides information regarding a body's stability and moments of inertia. The center of gravity does not always have to fall within the shape or boundaries of the body; it may also lie outside the body in certain cases.
To determine its location, the principle of moments can be utilized by dividing the object into...
To determine its location, the principle of moments can be utilized by dividing the object into...
2.2K
Center of Mass
2.0K
The center of mass is the point at which the total mass of an object can be said to be concentrated. It is a fundamental principle in mechanics and physics that applies to all objects regardless of their shape or size. The center of gravity is the point at which an object’s weight appears to be concentrated and can be used to balance the object perfectly.
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
The knowledge of the center of mass can also help us to describe and predict the motion of objects. For example, when a ball is thrown...
2.0K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.2K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.2K
Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K

