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Updated: Jan 31, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Rheumatoid arthritis and cardiovascular risk factor : literature review]
A A Zulfiqar1, R Niazi2, J L Pennaforte3
1Département de Médecine Interne-Gériatrie-Thérapeutique, Hôpital Saint-Julien, CHU Rouen, France.
Rheumatoid arthritis is a common condition posing diagnostic and treatment challenges, particularly in older adults. This review examines rheumatoid arthritis as a significant cardiovascular risk factor, highlighting its association with increased mortality from atherosclerosis.
Area of Science:
- Rheumatology
- Cardiology
- Geriatrics
Background:
- Rheumatoid arthritis (RA) is a prevalent autoimmune disease.
- RA presents significant diagnostic and therapeutic challenges, especially in the elderly population.
- RA is linked to elevated mortality rates, particularly from coronary and cerebrovascular atherosclerosis.
Purpose of the Study:
- To review the role of rheumatoid arthritis as a cardiovascular risk factor.
- To synthesize current literature on the association between RA and cardiovascular disease (CVD).
Main Methods:
- A comprehensive literature review was conducted.
- Searched databases for studies investigating RA and cardiovascular outcomes.
Main Results:
- Rheumatoid arthritis is an independent risk factor for cardiovascular disease.
- Patients with RA exhibit higher rates of atherosclerosis, myocardial infarction, and stroke.
- Inflammation associated with RA contributes to atherogenesis and cardiovascular events.
Conclusions:
- Rheumatoid arthritis significantly increases cardiovascular risk.
- Early detection and management of cardiovascular risk factors in RA patients are crucial.
- Further research is needed to elucidate mechanisms and optimize CVD prevention in RA.
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