[Symptoms of cellular immunity in chronic and lupus nephritis]

On the one hand, the results of our investigation reveal a hypersensitivity to renal antigen in patients with GN and LN. On the other hand, they refer to a change of the number of lymphocytes of the peripheral blood with a decrease of their functional activity. In patients with GN the sensibilisation of lymphocytes appeared in the same degree to the antigens of the renal extract as well as to the antigens of the basal membrane of the glomerulus. In contrast to this in the group of patients with LN the sensibility to antigens of the basal membrane was found only in 2 among 17 examined patients. The expression of the sensibilisation of lymphocytes to renal antigens correlated with the activity of clinical diseases and was most frequently connected with a higher pathological activity in patients with GN as well as in patients with LN. The analysis of RMHL and BMK did not show such legitimacies. In signs of the cellular immunity there could not be found any essential differences also in the examination of clinicomorphological variants of the GN.