Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:05

Long-term Depression

33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Reliability and Validity01:29

Reliability and Validity

13.9K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
13.9K
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

40.0K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.0K
Depressants01:28

Depressants

428
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
428
Depression: Overview01:18

Depression: Overview

879
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
879

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Co-Rumination with Peers Predicts Risk for Depression in Offspring of Mothers with Major Depressive Disorder.

Research on child and adolescent psychopathology·2026
Same author

Exploring Longitudinal Associations Among Error-Related Negativity, Perception of Interpersonal Events, and Internalizing Symptoms in Female Adolescents.

Research on child and adolescent psychopathology·2026
Same author

Editorial: Mechanism-specific developmental windows of opportunity in the prevention of youth psychopathology.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same author

Neighborhood Disadvantage as a Moderator of Children's Response to a Dyadic Positive Affect Intervention for Children of Mothers with Depressive Symptoms.

Journal of child and adolescent psychopharmacology·2026
Same author

Feasibility Trial of a Single Session of Crisis Response Planning for Youth at High Risk for Suicide.

Behavior therapy·2026
Same author

An examination of the influence of prefrontal cortical brain stimulation on sexual decision making.

Oxford open neuroscience·2026

Related Experiment Video

Updated: Jan 31, 2026

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation
10:25

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Published on: September 2, 2025

521

A multimethod screening approach for pediatric depression onset: An incremental validity study.

Joseph R Cohen1, Hena Thakur1, Katie L Burkhouse2

  • 1Department of Psychology.

Journal of Consulting and Clinical Psychology
|December 21, 2018
PubMed
Summary

Multi-informant screening and pupil dilation effectively predict pediatric depression onset. Elevated pupil dilation in youth with mild symptoms significantly increases their risk for developing depression.

More Related Videos

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

15.3K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

11.2K

Related Experiment Videos

Last Updated: Jan 31, 2026

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation
10:25

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Published on: September 2, 2025

521
A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors

Published on: December 7, 2014

15.3K
Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

11.2K

Area of Science:

  • Child and Adolescent Psychiatry
  • Developmental Psychology
  • Clinical Psychology

Background:

  • Single-informant screening is insufficient for predicting pediatric depression.
  • Multi-informant and risk factor approaches show promise but require validation.
  • Optimal algorithms for predicting youth depression onset need further investigation.

Purpose of the Study:

  • To test multi-indicator approaches for predicting depression onset in youth.
  • To identify an optimal screening algorithm for pediatric depression.
  • To assess the incremental validity of multi-informant and biological markers.

Main Methods:

  • A longitudinal study of 222 never-depressed children and adolescents.
  • Inclusion of self-report, maternal reports, interviews, and a pupil dilation task.
  • Follow-up diagnostic assessments every 6 months for 2 years.

Main Results:

  • Moderate support for multi-informant screening approaches.
  • Pupil dilation uniquely predicted depression onset.
  • Youth with subthreshold symptoms and elevated pupil dilation had over double the risk of depression onset.

Conclusions:

  • Development of a novel screening battery for first-episode pediatric depression.
  • Pupil dilation offers a feasible biological indicator for depression risk.
  • Enhanced screening can improve primary prevention of youth depression.