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Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
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LAP+ Treg is a better biomarker than total Treg in viral myocarditis

Xinggang Wang1, Junbo Ge1, Ruizhen Chen1

  • 1Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Journal of Medical Virology
|December 21, 2018
PubMed

Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells. Comparing with the previously recognized total Treg, LAP+ Treg was a better biomarker on myocardial inflammation.

Keywords:
inflammationlatency associated peptide (LAP+) regulatory T cells (Treg)viral myocarditis

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