Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 31, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.2K

[Chloroquine retinopathy].

A Ly Nguyen1,2, Annelie N Tan3, A P M Lavrijsen1

  • 1LUMC, afd. Dermatologie, Leiden.

Nederlands Tijdschrift Voor Geneeskunde
|December 21, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compromising human skin in vivo and ex vivo to study skin barrier repair.

Biochimica et biophysica acta. Molecular and cell biology of lipids·2019
Same author

Cellulitis: current insights into pathophysiology and clinical management.

The Netherlands journal of medicine·2017
Same author

Outcomes of severe uveitic glaucoma treated with Baerveldt implant: can blindness be prevented?

Acta ophthalmologica·2017
Same author

Attentional processing of itch.

Psychological research·2017
Same author

Corneal endothelial cell loss after Baerveldt glaucoma drainage device implantation in the anterior chamber.

Acta ophthalmologica·2016
Same author

[A man with skin lesions of his face].

Nederlands tijdschrift voor geneeskunde·2016
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Chloroquine (CQ) and hydroxychloroquine (HCQ) can cause irreversible retinopathy, especially with long-term use or high doses. Regular eye exams are crucial for early detection and management of this serious complication.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Background:

  • Chloroquine (CQ) and hydroxychloroquine (HCQ) are medications used to treat various autoimmune conditions.
  • These drugs are known to potentially cause retinopathy, a severe and irreversible complication affecting vision.
  • Risk factors for developing retinopathy include prolonged treatment duration (> 5 years), higher dosages, renal failure, tamoxifen use, and pre-existing eye conditions.

Observation:

  • A case of bull's-eye maculopathy is presented in a 46-year-old woman with chronic discoid lupus erythematosus.
  • The patient was treated with chloroquine (CQ) at doses of 100-300 mg/day for five years.
  • CQ treatment was discontinued after the development of maculopathy.

Findings:

  • The risk of CQ/HCQ-induced retinopathy escalates with treatment duration and dosage.

More Related Videos

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

377
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

9.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
08:22

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

5.2K
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

377
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents
09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

9.4K
  • Specific dosage thresholds for increased risk are identified: CQ > 2.3 mg/kg/day and HCQ > 5.0 mg/kg/day.
  • Concomitant factors like renal failure and tamoxifen use significantly elevate retinopathy risk.

    • Implications:

    • Routine ophthalmological screening is recommended for all patients on CQ or HCQ within one year of treatment initiation.
    • Annual eye examinations are advised for patients without risk factors, starting one year (CQ) or five years (HCQ) into treatment.
    • Regular reassessment of risk factors is essential to tailor the frequency of ophthalmological monitoring and prevent vision loss.