Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sympathetic Activation01:16

Sympathetic Activation

7.0K
The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
7.0K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

103.5K
Overview
103.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

561
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
561
Sympathetic Signaling01:31

Sympathetic Signaling

2.5K
Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
2.5K
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

6.3K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
6.3K
Masking and Demasking Agents01:19

Masking and Demasking Agents

3.6K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of small-molecule HSF1 amplifiers by high content screening in protection of cells from stress induced injury.

Biochemical and biophysical research communications·2009
Same author

Nanowire transformation by size-dependent cation exchange reactions.

Nano letters·2009
Same author

Effect of haishengsu as an adjunct therapy for patients with advanced renal cell cancer: a randomized and placebo-controlled clinical trial.

Journal of alternative and complementary medicine (New York, N.Y.)·2009
Same author

Identification of inhibitors of HSF1 functional activity by high-content target-based screening.

Journal of biomolecular screening·2009
Same author

Antitumor effects of targeting hTERT lentivirus-mediated RNA interference against KB cell lines.

Oncology research·2009
Same author

Characteristics of emissive spectrum and the removal of nitric oxide in N2/02/NO plasma with argon additive.

Journal of environmental sciences (China)·2009

Related Experiment Video

Updated: Jan 31, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.1K

Out-of-Clinic Sympathetic Activity Is Increased in Patients With Masked Uncontrolled Hypertension.

Mohammed Siddiqui1, Eric K Judd2, Byron C Jaeger3

  • 1From the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease (M.S., T.D., S.O., D.A.C.), University of Alabama at Birmingham.

Hypertension (Dallas, Tex. : 1979)
|December 21, 2018
PubMed
Summary

Masked uncontrolled hypertension (MUCH) involves controlled clinic blood pressure (BP) but high out-of-clinic BP. MUCH patients show increased sympathetic activity outside the clinic compared to truly controlled hypertensive individuals.

Keywords:
blood pressurecatecholaminesheart ratehypertensionmasked hypertension

More Related Videos

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.6K
Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.3K

Related Experiment Videos

Last Updated: Jan 31, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.1K
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
08:08

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets

Published on: May 11, 2015

14.6K
Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

8.3K

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Autonomic Nervous System

Background:

  • Masked uncontrolled hypertension (MUCH) is characterized by normal in-clinic blood pressure (BP) readings but elevated out-of-clinic BP.
  • Understanding the physiological mechanisms underlying MUCH is crucial for effective hypertension management.
  • Previous research suggests potential differences in sympathetic nervous system activity between MUCH and true controlled hypertension.

Purpose of the Study:

  • To investigate whether patients with masked uncontrolled hypertension exhibit greater out-of-clinic sympathetic activity compared to true controlled hypertensives.
  • To compare in-clinic and out-of-clinic sympathetic markers in patients with MUCH and true controlled hypertension.

Main Methods:

  • Prospective recruitment of 237 hypertensive patients on medication.
  • Evaluation included in-clinic automated office BP, plasma catecholamines, spot-urine/plasma metanephrines, 24-hour ambulatory BP monitoring (ABPM), and 24-hour urinary catecholamines/metanephrines.
  • Analysis of 72 true controlled hypertensives and 80 MUCH patients based on BP control in-clinic and out-of-clinic.

Main Results:

  • MUCH patients demonstrated significantly higher out-of-clinic BP variability and lower heart rate variability compared to true controlled hypertensives.
  • Elevated out-of-clinic urinary catecholamines and metanephrines were observed in MUCH patients, indicating heightened sympathetic activity.
  • No significant differences in in-clinic plasma catecholamines or spot-urine/plasma metanephrines were found between the groups.

Conclusions:

  • Masked uncontrolled hypertension is associated with heightened sympathetic nervous system activity specifically during out-of-clinic conditions.
  • These findings suggest that increased out-of-clinic sympathetic drive may play a role in the pathophysiology of MUCH.
  • Further research is warranted to explore the clinical implications and therapeutic strategies for managing MUCH.