Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromosome Structure02:40

Chromosome Structure

26.4K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.4K
Polytene Chromosomes02:04

Polytene Chromosomes

11.0K
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also...
11.0K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

8.7K
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
8.7K
Chromosome Replication02:31

Chromosome Replication

10.6K
Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
10.6K
Chromosomal Theory of Inheritance01:39

Chromosomal Theory of Inheritance

60.2K
In 1866, Gregor Mendel published the results of his pea plant breeding experiments, providing evidence for predictable patterns in the inheritance of physical characteristics. The significance of his findings was not immediately recognized. In fact, the existence of genes was unknown at the time. Mendel referred to hereditary units as “factors.”
60.2K
Areas Within Irregular Boundaries01:26

Areas Within Irregular Boundaries

382
Calculating areas within irregular boundaries, such as along rivers or curved roads, is crucial in various fields, including surveying, engineering, and environmental management. Surveyors often begin by creating a traverse, a connected series of straight lines approximating the area's boundary. The coordinates of each traverse point are essential for calculating the enclosed area. The double meridian distance formula is a widely used technique for this purpose. This method utilizes the...
382

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Getting the timing right. Autistic adolescents reflect on the value of an early diagnosis.

Frontiers in psychiatry·2026
Same author

Bioethics-in-Science : An Invitation.

Journal of bioethical inquiry·2026
Same author

Narratives and tensions in the ethics of human proteomics literature: a scoping review.

BMC medical ethics·2026
Same author

Imagining an ethics for synthetic biology.

Frontiers in genetics·2026
Same author

Exploring MAR perceptions in Kosovo - disparities in knowledge about MAR among young people.

Open research Europe·2026
Same author

Attuning to the deep on the opportunities of thinking with art for an ethics and science of the deep sea.

History and philosophy of the life sciences·2025

Related Experiment Video

Updated: Jan 31, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

7.7K

Blurring boundaries. Interviews with PGT couples about comprehensive chromosome screening.

Kristien Hens1, Maryse Bonduelle2, Christine de Die-Smulders3

  • 1University of Antwerp, Department of Philosophy, Rodestraat 14, 2000, Antwerp, Belgium.

European Journal of Medical Genetics
|December 21, 2018
PubMed
Summary

Comprehensive chromosome screening in Preimplantation Genetic Testing (PGT) offers benefits but raises ethical questions. Patient perspectives on embryo viability and professional roles differ, highlighting the need for clear communication in fertility treatments.

Keywords:
Comprehensive chromosome screeningEthicsPreimplantation genetic testingQualitative research

More Related Videos

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.7K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.8K

Related Experiment Videos

Last Updated: Jan 31, 2026

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome
11:15

Pooled shRNA Screen for Reactivation of MeCP2 on the Inactive X Chromosome

Published on: March 2, 2018

7.7K
Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis
12:32

Chromosome Screening of Human Preimplantation Embryos by Using Spent Culture Medium: Sample Collection and Chromosomal Ploidy Analysis

Published on: September 7, 2021

2.7K
HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

8.8K

Area of Science:

  • Reproductive medicine
  • Clinical genetics
  • Bioethics

Background:

  • Comprehensive chromosome examination is an advanced method in Preimplantation Genetic Testing (PGT).
  • It allows for the assessment of all chromosomes, potentially improving pregnancy rates and reducing miscarriage risks.
  • However, it introduces complex ethical considerations regarding embryo viability and communication.

Purpose of the Study:

  • To explore the ethical issues associated with comprehensive chromosome screening in PGT.
  • To understand patient perspectives on embryo selection and the role of healthcare professionals.

Main Methods:

  • Qualitative study involving interviews with seven couples undergoing PGT for chromosomal translocations.
  • Presentation of three fictional cases involving different chromosomal abnormalities (e.g., trisomy 21, sex chromosome aneuploidy, microdeletion).

Main Results:

  • Patient opinions on the role of fertility professionals in embryo transfer decisions were varied.
  • There was ambiguity regarding the definition of 'healthy' versus 'unhealthy' embryos.
  • Couples perceived extended waiting times for embryo transfer as a significant drawback, despite acknowledging potential benefits of comprehensive testing.

Conclusions:

  • Patient views on the benefits and burdens of comprehensive chromosome screening in PGT may not align with those of healthcare professionals.
  • Ethical guidelines and communication strategies need to consider diverse patient perspectives in fertility treatment.