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Development and Applications of Prognostic Risk Models in the Management of Invasive Mold Disease
Marta Stanzani1, Russell E Lewis2
1Institute of Hematology "Lorenzo e Ariosto Seràgnoli", Department of Hematology and Clinical Oncology, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy. marta.stanzani2@unibo.it.
Abstract:
Prognostic models or risk scores are frequently used to aid individualize risk assessment for diseases with multiple, complex risk factors and diagnostic challenges. However, relatively little attention has been paid to the development of risk models for invasive mold diseases encountered in patients with hematological malignancies, despite a large body of epidemiological research. Herein we review recent studies that have described the development of prognostic models for mold disease, summarize our experience with the development and clinical use of one such model (BOSCORE), and discuss the potential impact of prognostic risk scores for individualized therapy, diagnostic and antifungal stewardship, as well as clinical and epidemiological research.
Insights
Developing prognostic models for invasive mold diseases in hematological malignancy patients is crucial. These risk scores can personalize treatment, improve diagnostics, and guide antifungal stewardship for better patient outcomes.
Area of Science:
- Medical Mycology
- Hematology
- Epidemiology
Background:
- Prognostic models are vital for assessing complex diseases.
- Risk models for invasive mold diseases in hematological malignancy patients are under-developed.
- Epidemiological research on mold diseases in these patients is extensive.
Purpose of the Study:
- To review the development of prognostic models for mold disease.
- To summarize experience with the BOSCORE model for invasive mold diseases.
- To discuss the impact of prognostic risk scores on patient care and research.
Main Methods:
- Literature review of recent studies on prognostic models for mold disease.
- Summary of the development and clinical application of the BOSCORE model.
- Discussion of the implications of prognostic risk scores.
Main Results:
- Recent studies have focused on developing prognostic models for mold disease.
- The BOSCORE model has been developed and used clinically.
- Prognostic risk scores have potential impacts on therapy, diagnostics, and stewardship.
Conclusions:
- There is a need for more research and development of risk models for invasive mold diseases in hematological malignancy patients.
- The BOSCORE model serves as an example of a clinical tool for risk stratification.
- Prognostic risk scores can significantly influence individualized therapy, diagnostic strategies, and antifungal stewardship.
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