Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing...

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Stimuli-sensitive and biodegradable hydrogels are crucial for advanced drug delivery.
• Developing novel hydrogel systems with tailored properties is essential for biomedical applications.

Purpose of the Study:

• To construct and characterize hybrid hydrogels from peptide-based bis-acrylate and acrylic acid (AAc).
• To evaluate the stimuli-sensitivity, biodegradability, mechanical properties, and cytotoxicity of the developed hydrogels.
• To investigate the potential of these hydrogels as drug delivery systems for antibacterial wound dressings.

Main Methods:

• Hybrid hydrogels were synthesized using peptide-based bis-acrylate and acrylic acid.
• Scanning electron microscopy (SEM) was used to observe the hydrogel structure and biodegradation.
• Swelling, biodegradation, mechanical, and cytotoxicity properties were evaluated.
• Drug release and antibacterial studies were conducted with preloaded triclosan.

Main Results:

• The peptide-based bis-acrylate/AAc hydrogel exhibited a porous structure and pH-dependent swelling.
• Good enzymatic biodegradation properties were confirmed through SEM and weight loss analysis.
• The hydrogels demonstrated suitable mechanical properties and low cytotoxicity.
• Successful drug (triclosan) release and antibacterial activity were observed.

Conclusions:

• The synthesized peptide-based bis-acrylate/AAc hydrogels possess desirable stimuli-sensitive and biodegradable characteristics.
• These hybrid hydrogels show significant potential as effective drug delivery systems.
• The findings support their application in antibacterial wound dressing formulations.