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[Clinical features and risk factors of pertussis in children]

Feng-Yan Liu1, Feng Shao

  • 1Disease Screening Center, Tai'an Maternal and Child Health Care Hospital, Tai'an, Shandong 271000, China. 8338602@sina.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 22, 2018
PubMed

Insights

Pertussis in children often presents with atypical symptoms. Lack of timely immunization and contact with infected individuals are key risk factors, highlighting the importance of vaccination and isolation.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Pertussis, or whooping cough, remains a significant public health concern in children.
  • Clinical presentation of pertussis can be variable, complicating early diagnosis.

Purpose of the Study:

  • To investigate the clinical characteristics of pertussis in hospitalized children.
  • To identify risk factors associated with pertussis infection in pediatric populations.

Main Methods:

  • Retrospective analysis of clinical and immunological data from 253 children with pertussis and 314 controls.
  • Quantitative real-time PCR used for Bordetella pertussis DNA detection.
  • Risk factor analysis comparing clinical parameters and immunization history.

Main Results:

  • Only 10 out of 23 clinical parameters showed significant differences between pertussis and control groups.
  • Lower incidence of myocarditis and reduced serum globulin/IgM levels observed in pertussis cases.
  • Lack of timely diphtheria-pertussis-tetanus (DPT) immunization and contact with suspected cases were significant risk factors.

Conclusions:

  • Clinical features of pertussis in children are frequently atypical.
  • Quantitative real-time PCR aids in diagnosing atypical pertussis.
  • Timely DPT immunization and isolation from infected individuals are crucial for prevention.
Abstract

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