Access Site and Outcomes for Unprotected Left Main Stem Percutaneous Coronary Intervention: An Analysis of the

Tim Kinnaird1, Richard Anderson2, Sean Gallagher2

  • 1Department of Cardiology, University Hospital of Wales, Cardiff, United Kingdom; Keele Cardiovascular Research Group, Institute of Applied Clinical Sciences, University of Keele, Stoke-on-Trent, United Kingdom.

Insights

Radial access (RA) is now the preferred arterial access site for unprotected left main stem percutaneous coronary intervention (LMS-PCI). RA use leads to shorter hospital stays and fewer vascular complications compared to femoral access (FA).

Area of Science:

  • Cardiovascular Interventions
  • Interventional Cardiology
  • Vascular Access Techniques

Background:

  • Arterial access site selection for unprotected left main stem percutaneous coronary intervention (LMS-PCI) remains poorly defined.
  • Understanding trends and outcomes associated with different access sites is crucial for optimizing patient care.

Purpose of the Study:

  • To analyze temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected LMS-PCI.
  • To evaluate the impact of access site choice on procedural success, complications, and patient outcomes.

Main Methods:

  • Analysis of 19,482 unprotected LMS-PCI procedures from the British Cardiovascular Intervention Society PCI database (2007-2014).
  • Multivariate logistic regression to identify predictors of access site choice and its association with outcomes.
  • Propensity matching to compare outcomes between RA and FA groups.

Main Results:

  • Femoral access (FA) use decreased significantly from 77.7% in 2007 to 31.7% in 2014.
  • Radial access (RA) use was associated with shorter length of stay, higher same-day discharge rates, and reduced in-hospital complications (arterial complications, major bleeding, MACE).
  • RA use did not significantly impact 12-month mortality.

Conclusions:

  • Radial artery has become the predominant access site for unprotected LMS-PCI in contemporary practice.
  • RA use is linked to improved short-term outcomes, including reduced vascular complications and bleeding, compared to FA.
  • Further research may explore long-term outcomes and specific patient selection criteria for RA in complex LMS-PCI procedures.
Abstract

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