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Updated: Jan 31, 2026

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Published on: March 15, 2022
Access Site and Outcomes for Unprotected Left Main Stem Percutaneous Coronary Intervention: An Analysis of the
Tim Kinnaird1, Richard Anderson2, Sean Gallagher2
1Department of Cardiology, University Hospital of Wales, Cardiff, United Kingdom; Keele Cardiovascular Research Group, Institute of Applied Clinical Sciences, University of Keele, Stoke-on-Trent, United Kingdom.
Insights
Radial access (RA) is now the preferred arterial access site for unprotected left main stem percutaneous coronary intervention (LMS-PCI). RA use leads to shorter hospital stays and fewer vascular complications compared to femoral access (FA).
Area of Science:
- Cardiovascular Interventions
- Interventional Cardiology
- Vascular Access Techniques
Background:
- Arterial access site selection for unprotected left main stem percutaneous coronary intervention (LMS-PCI) remains poorly defined.
- Understanding trends and outcomes associated with different access sites is crucial for optimizing patient care.
Purpose of the Study:
- To analyze temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected LMS-PCI.
- To evaluate the impact of access site choice on procedural success, complications, and patient outcomes.
Main Methods:
- Analysis of 19,482 unprotected LMS-PCI procedures from the British Cardiovascular Intervention Society PCI database (2007-2014).
- Multivariate logistic regression to identify predictors of access site choice and its association with outcomes.
- Propensity matching to compare outcomes between RA and FA groups.
Main Results:
- Femoral access (FA) use decreased significantly from 77.7% in 2007 to 31.7% in 2014.
- Radial access (RA) use was associated with shorter length of stay, higher same-day discharge rates, and reduced in-hospital complications (arterial complications, major bleeding, MACE).
- RA use did not significantly impact 12-month mortality.
Conclusions:
- Radial artery has become the predominant access site for unprotected LMS-PCI in contemporary practice.
- RA use is linked to improved short-term outcomes, including reduced vascular complications and bleeding, compared to FA.
- Further research may explore long-term outcomes and specific patient selection criteria for RA in complex LMS-PCI procedures.
Objectives:
Using the British Cardiovascular Intervention Society percutaneous coronary intervention (PCI) database, temporal trends, predictors, and outcomes of radial access (RA) versus femoral access (FA) for unprotected left main stem percutaneous coronary intervention (LMS-PCI) were studied.
Background:
Data on arterial access site for LMS-PCI are poorly defined.
Methods:
Data were analyzed from 19,482 LMS-PCI procedures performed in England and Wales between 2007 and 2014. Multivariate logistic regression was used to identify predictors of access site choice and its association with outcomes.
Results:
The frequency of FA use fell from 77.7% in 2007 to 31.7% in 2014 (p < 0.001 for trend). In the most contemporary study years (2012 to 2014), the strongest associates of FA use for unprotected LMS-PCI were renal disease, PCI for restenosis, chronic total occlusion intervention, and female sex. Use of intravascular imaging and chronic anticoagulation were associated with a higher likelihood of RA use. Complexity of the PCI procedure in the RA cohort increased significantly during the study period. Length of stay was shorter (2.6 ± 9.2 vs. 3.6 ± 9.0; p < 0.001) and same day discharge greater (43.0% vs. 26.6%; p < 0.001) with RA use. After propensity matching, RA use was associated with significant reductions in in-hospital events including access site arterial complications, major bleeding, and major adverse cardiovascular events. Conversion to RA for LMS-PCI was associated with similar reductions in the whole patient cohort. RA use was not associated with lower 12-month mortality.
Conclusions:
In contemporary practice, the radial artery is the predominant access site for unprotected LMS-PCI, and its use is associated with shorter length of stay, less vascular complications, and less major bleeding than femoral access.
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