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Impaired Visual Search in Children with Rett Syndrome.

Susan A Rose1, Sam Wass2, Jeffery J Jankowski3

  • 1Department of Pediatrics, Montefiore Medical Center, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Bronx, New York.

Pediatric Neurology
|December 22, 2018
PubMed
Summary
This summary is machine-generated.

Selective attention is impaired in Rett syndrome (RTT), a neurodevelopmental disorder. Gaze-based tasks reveal difficulties in visual search for individuals with RTT, offering insights into their cognitive phenotype.

Keywords:
ChildrenEye-trackingRett syndromeSearchSelective attention

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Ophthalmology

Background:

  • Rett syndrome is a severe neurodevelopmental disorder caused by MECP2 gene mutations.
  • Selective attention is crucial for processing environmental stimuli.

Purpose of the Study:

  • To investigate selective attention deficits in individuals with Rett syndrome.
  • To compare visual search performance in Rett syndrome patients and typically developing controls.

Main Methods:

  • Utilized a visual search task with eye-tracking technology.
  • Included 28 females with Rett syndrome and 32 controls.
  • Presented stimuli with single-feature (pop-out) or feature-conjunction (serial search) distractors.

Main Results:

  • Individuals with Rett syndrome exhibited significantly lower success rates (less than 50%) compared to controls (80%).
  • Rett syndrome patients showed prolonged response times, irrespective of display size or age.
  • Saccadic latency differences were noted in the single-feature condition, with both groups slowing in the conjunction-feature condition.

Conclusions:

  • Selective attention is demonstrably compromised in Rett syndrome.
  • Gaze-based tasks are valuable for assessing the cognitive phenotype of Rett syndrome.