Related Experiment Video

Updated: Jan 31, 2026

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.8K

Long non-coding RNA FENDRR inhibits proliferation and invasion of hepatocellular carcinoma by down-regulating

Bian Wang1, Jianchun Xian1, Jinfeng Zang2

  • 1Department of Liver Disease, Taizhou people's Hospital affiliated of Nantong University of medicine, Taizhou, China.

Biochemical and Biophysical Research Communications
|December 22, 2018
PubMed

Insights

Long non-coding RNA FENDRR acts as a tumor suppressor in hepatocellular carcinoma (HCC). Restoring FENDRR inhibits HCC cell growth, migration, and invasion by epigenetically targeting Glypican-3 (GPC3).

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Long non-coding RNA FENDRR's role in hepatocellular carcinoma (HCC) remains largely uncharacterized.
  • FENDRR is implicated in the progression of various cancers.

Purpose of the Study:

  • To investigate the expression and biological functions of FENDRR in HCC.
  • To elucidate the underlying molecular mechanisms of FENDRR action in HCC.

Main Methods:

  • Quantitative analysis of FENDRR expression in HCC tissues and cell lines.
  • In vitro and in vivo assays to assess FENDRR's effects on HCC cell proliferation, migration, and invasion.
  • Chromatin immunoprecipitation and methylation analysis to determine FENDRR's interaction with the Glypican-3 (GPC3) promoter.

Main Results:

  • FENDRR expression was significantly downregulated in HCC tissues and cells.
  • FENDRR overexpression inhibited HCC cell growth, migration, and invasion.
  • FENDRR directly methylated the GPC3 promoter, leading to GPC3 downregulation.
  • Ectopic GPC3 expression reversed the inhibitory effects of FENDRR.

Conclusions:

  • FENDRR acts as a tumor suppressor in HCC by epigenetically targeting GPC3.
  • FENDRR inhibits HCC progression and metastasis through GPC3 downregulation.
  • Restoration of FENDRR presents a potential therapeutic strategy for HCC.
Keywords:
EpigeneticGlypican-3Hepatocellular carcinomaLong non-coding RNA FENDRRProgression and metastasis

More Related Videos

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma07:47

Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

Published on: August 31, 2022

2.8K
A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis05:06

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

Published on: October 24, 2015

12.9K

Related Concept Videos

Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

4.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.7K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K