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High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases
C D Spyris1, R C Castellino2,3, M J Schniederjan4
1From the Departments of Radiology and Imaging Sciences (C.D.S., N.K.).
Abstract:
High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.
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