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Cross-Modal Competition: The Default Computation for Multisensory Processing.

Liping Yu1, Cristiano Cuppini2, Jinghong Xu1

  • 1Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science, East China Normal University, Shanghai 200062, China.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 22, 2018
PubMed
Summary
This summary is machine-generated.

Multisensory neurons in the superior colliculus (SC) initially compete, not integrate, cross-modal signals. Experience shifts this default competition to cooperation, enhancing sensory processing and behavior.

Keywords:
computational modelingenhancementinhibitionintegrationplasticitysuperior colliculus

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Area of Science:

  • Neuroscience
  • Sensory processing
  • Developmental neuroscience

Background:

  • Mature superior colliculus (SC) neurons integrate multisensory information for enhanced responses to congruent stimuli.
  • This integration develops through experience with cross-modal cues.
  • Naive SC neurons were previously thought to not interact cross-modally.

Purpose of the Study:

  • To investigate cross-modal interactions in naive superior colliculus (SC) neurons.
  • To challenge the prevailing view of non-integration in naive multisensory neurons.
  • To explore the developmental transition from naive to mature multisensory processing.

Main Methods:

  • Studied visual-auditory cross-modal cue interactions in naive male and female cats.
  • Manipulated the relative effectiveness of visual and auditory cues presented to SC neurons.
  • Utilized a neuro-computational model to explain observed interactions.

Main Results:

  • Identified active competition between visual and auditory signals in naive SC neurons.
  • Demonstrated that the default state of naive SC neurons is mutual inhibition, not non-interaction.
  • Showed that experience transitions SC neurons from competition to cooperation.

Conclusions:

  • The default mode of multisensory processing in the SC is competition, mediated by mutual inhibition.
  • Multisensory neurons integrate cross-modal stimuli through experience, moving from competition to cooperation.
  • This developmental shift enhances the salience of cross-modal events, impacting sensorimotor circuitry and behavior.