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Mathematical-model-guided development of full-thickness epidermal equivalent.

Junichi Kumamoto1, Shinobu Nakanishi2, Mio Makita2

  • 1Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan.

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|December 22, 2018
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Summary

Mathematical modeling accurately predicted epidermal thickness. Researchers created a realistic 3D skin model using keratinocytes on patterned textiles, achieving excellent barrier function and mimicking human epidermis.

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Area of Science:

  • Tissue engineering
  • Biomaterials science
  • Mathematical modeling

Background:

  • Current epidermal models lack physiological thickness (10-20 μm vs. 100 μm in vivo).
  • Mathematical modeling of epidermal homeostasis suggested papillary layer undulations dictate epidermal thickness.

Purpose of the Study:

  • To test the hypothesis that papillary layer structure influences epidermal thickness.
  • To develop a more physiologically realistic epidermal model using passaged keratinocytes and biomimetic substrates.

Main Methods:

  • Human keratinocytes were cultured on polyester textiles with varied fiber patterns.
  • The engineered epidermal model was analyzed for structural, cellular, and barrier properties.
  • Gene silencing of YAP (Yes-associated protein) was performed to assess its role.

Main Results:

  • Textile patterns matching model predictions yielded a 3D epidermal model with a thick stratum corneum and functional barrier.
  • The basal layer mimicked the human papillary layer, with proliferating cells expressing key markers.
  • Appropriate expression of filaggrin, loricrin, claudin 1, and ZO-1 was observed.
  • YAP (Yes-associated protein) silencing disrupted the 3D structure.

Conclusions:

  • Mathematical modeling provides predictive insights for biological processes.
  • Biomimetic textile scaffolds can generate physiologically relevant epidermal equivalents.
  • This approach enhances skin tissue engineering and barrier function studies.