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Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches

Zoe Michael1,2, Fotios Spyropoulos1,2,3, Sailaja Ghanta1,2

  • 1Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Clinical Medicine Insights. Pediatrics
|December 22, 2018
PubMed

Insights

Bronchopulmonary dysplasia (BPD) affects extremely preterm infants, with limited impact from new interventions. This review examines current and future pharmacologic treatments for BPD.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Pharmacology

Background:

  • Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in extremely preterm infants.
  • Despite advances in neonatal care improving survival, BPD incidence remains high in extremely low birth weight (ELBW) infants.
  • The complex etiology of BPD necessitates multifaceted prevention and treatment strategies.

Purpose of the Study:

  • To review the current evidence for pharmacotherapy in the management of BPD.
  • To discuss novel and emerging pharmacologic interventions for BPD.
  • To highlight areas for future research in BPD pharmacotherapy.

Main Methods:

  • Systematic review of existing literature on pharmacologic treatments for BPD.
  • Analysis of clinical trial data and observational studies.
  • Evaluation of preclinical research for novel therapeutic targets.

Main Results:

  • Current pharmacotherapies show limited efficacy in preventing or treating BPD.
  • Several agents are under investigation, including corticosteroids, diuretics, and bronchodilators.
  • Emerging therapies target inflammation, lung repair, and vascular development.

Conclusions:

  • Pharmacotherapy plays a role in managing BPD symptoms and complications.
  • Further research is crucial to identify effective and safe pharmacologic treatments for BPD.
  • A combination of interventions, including pharmacotherapy, is likely necessary for optimal BPD management.

Keywords:
long-term lung disease of prematuritylong-term pulmonary insufficiency

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