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Standardization of the HbA2 Assay
Renata Paleari1, Andrea Mosca1
1Department of Physiopathology and Transplantation, Center for Metrological Traceability in Laboratory Medicine (CIRME), University of Milano, Italy.
Background:
A project for the standardization of HbA2 was launched by the IFCC back in 2004.
Materials And Methods:
In this work we report on the state-of-the-art of the project on standardization of HbA2. Data obtained from various EQAS studies, and from previous experimental evaluations, are presented.
Results:
We have proven that biases between various commercial methods are still currently significant. We have also shown that calibration by commutable control materials may halve the inter-method variability.
Conclusions:
The foundation of the reference system for HbA2, together with a brief preliminary presentation of the proposed primary reference measurement procedure based on ID-MS are outlined.
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