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Updated: Jan 31, 2026
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A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
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Devic syndrome and pregnancy: A case series.
Danielle Wuebbolt1,2, Vanessa Nguyen1,2, Rohan D'Souza2
1Division of Maternal and Fetal Medicine, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Obstetric Medicine
|December 22, 2018
Summary
Neuromyelitis optica (NMO) in pregnancy often leads to symptom worsening, but multidisciplinary care shows encouraging outcomes for affected women and their babies.
Area of Science:
- Neurology
- Autoimmune Diseases
- Reproductive Medicine
Background:
- Neuromyelitis optica (NMO) is a relapsing autoimmune neurological disorder.
- Women with NMO face increased risks of adverse pregnancy outcomes and relapses during and after pregnancy.
Purpose of the Study:
- To describe the management and outcomes of pregnancies in women with neuromyelitis optica.
- To evaluate the impact of NMO on pregnancy and the postpartum period.
Main Methods:
- A case series of 13 pregnancies in four women with NMO was conducted.
- Management involved a multidisciplinary team at a tertiary hospital.
Main Results:
- Neurologic symptoms frequently worsened or appeared during pregnancy/postpartum.
- Treatments included steroids, immunosuppressants, plasma exchange, and IVIG.
- 13 pregnancies resulted in 2 miscarriages, 3 preterm births, and 8 term births, with one case of congenital malformations.
Conclusions:
- Pregnancy in women with NMO is associated with a high relapse frequency.
- Multidisciplinary management leads to encouraging outcomes despite disease activity.
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