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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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Managing advanced HR-positive, HER2-negative breast cancer with CDK4/6 inhibitors in post-menopausal patients: is

Lorenzo Rossi1, Amelia McCartney1, Emanuela Risi1

  • 1'Sandro Pitigliani' Medical Oncology Department, Hospital of Prato, Prato, Italy.

Therapeutic Advances in Medical Oncology
|December 22, 2018
PubMed

Insights

The therapeutic landscape for HER2-negative metastatic breast cancer is evolving with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors. This commentary focuses on the optimal sequencing of CDK4/6 inhibitors for luminal mBC.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • The treatment of HER2-negative metastatic breast cancer (mBC) is rapidly changing with new targeted therapies.
  • Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors like palbociclib, ribociclib, and abemaciclib have shown efficacy in clinical trials.

Discussion:

  • Landmark trials demonstrate the benefits of CDK4/6 inhibitors in improving progression-free survival and overall response rates.
  • The optimal sequencing of CDK4/6 inhibitors in luminal mBC remains a critical clinical question.
  • This commentary addresses the best sequence for CDK4/6 inhibitors within the evolving treatment paradigm.

Key Insights:

  • CDK4/6 inhibitors are a significant advancement in treating luminal HER2-negative mBC.
  • Clinical trial data support the use of palbociclib, ribociclib, and abemaciclib.
  • Determining the optimal sequence of these agents is crucial for maximizing patient outcomes.

Outlook:

  • Further research is needed to establish definitive sequencing strategies for CDK4/6 inhibitors.
  • Personalized treatment approaches may guide the selection and sequencing of therapies.
  • The evolving therapeutic landscape requires ongoing evaluation of treatment efficacy and sequencing.
Keywords:
CDK4/6 inhibitorsabemaciclibbest-sequence therapymetastatic breast cancerpalbociclibribociclib

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