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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine.

X Michelle Androulakis1,2, Kaitlin A Krebs1, Charmaine Jenkins1

  • 1Division of Neurology, WJB Dorn VA Medical Center, Columbia, SC, USA.

Journal of Neurological Disorders
|December 22, 2018
PubMed
Summary
This summary is machine-generated.

Chronic migraine (CM) shows decreased brain network connectivity, particularly in the Central Executive Network (CEN). Medication overuse headache (MOH) in CM leads to more widespread disruptions in these networks.

Keywords:
Central executive networkChronic migraineDefault mode networkFunctional MRIMedication overuse headache

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Chronic migraine (CM) mechanisms are poorly understood, but linked to reduced intrinsic brain network connectivity.
  • Investigating neural network alterations is crucial for understanding CM pathophysiology.

Purpose of the Study:

  • To analyze functional connectivity within the Central Executive Network (CEN) and Default Mode Network (DMN) in chronic migraine (CM).
  • To compare CM patients with and without medication overuse headache (MOH) to healthy controls.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess node-to-node functional connectivity (NTNC).
  • Analysis included 136 CEN NTNC pairs and 6 DMN NTNC pairs in CM (n=13), CM with MOH (CMMOH, n=16), and controls.

Main Results:

  • Both CM and CMMOH groups exhibited decreased CEN connectivity, including between prefrontal cortex (PFC) regions and the anterior thalamus.
  • CMMOH showed more widespread CEN disruptions than CM when compared to controls.
  • Specific decreased connectivity within the CEN (right inferior frontal gyrus to left dorsolateral PFC) was noted in CMMOH compared to CM.

Conclusions:

  • Similar patterns of CEN connectivity dysfunction exist in CM, irrespective of MOH status.
  • Medication overuse headache exacerbates intranetwork disruptions within the CEN in chronic migraine patients.
  • Altered connectivity in CM may relate to impaired cognitive control and pain regulation, with more severe deficits in CMMOH.