Nonalcoholic Fatty Liver Disease and Urolithiasis. A Systematic Review and Meta-Analysis
Karn Wijarnpreecha1, Susan Lou2, Panadeekarn Panjawatanan3
1Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY; Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Jacksonville, Florida, USA.
Background And Aims:
Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) could be a predisposing factor for urolithiasis but the results have been inconsistent. This systematic review and meta-analysis was conducted with the aim to summarize all available data.
Methods:
A comprehensive literature review was conducted using MEDLINE and EMBASE databases through March 2018 to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus those without NAFLD. Effect estimates from each study were extracted and combined together using the random-effect, generic inverse variance method of DerSimonian and Laird.
Results:
A total of eight studies with 238,400 participants fulfilled the eligibility criteria and were included in the meta-analysis. The risk of urolithiasis among patients with NAFLD was significantly higher than in those without NAFLD with a pooled odds ratio of 1.81 (95% confidence interval, 1.29-2.56; I2 92%).
Conclusions:
A significantly increased risk of urolithiasis among patients with NAFLD was observed in this meta-analysis.
More Related Videos
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
04:34Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
Published on: February 17, 2023
Related Concept Videos
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Random and Systematic Errors
Directing Effect of Substituents: meta-Directing Groups
