Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems
Yanjing Yang1, Shian Zhong2, Kemin Wang3
1College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, PR China and State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China. jinhuang@hnu.edu.cn.
Abstract:
Gold nanoparticles (AuNPs) with unique physical and chemical properties have become an integral part of research in nanoscience. In particular, the development of AuNP-based fluorescent oligonucleotide (AuFO) probes targeted at living systems through fluorescence are drawing increasing attention and have become a current hot topic in biomedical research. This review describes recent advances and developments in the use of AuFO probes from their preparation and features that allow the desired intracellular delivery to their applications in cellular imaging and drug delivery in living systems.
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