Related Experiment Video
Updated: Jan 31, 2026
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
Published on: August 5, 2014
Long-term reactions to pulsatile tinnitus are marked by weakened short-range functional connectivity within a brain
Wang Zheng1, Zhang Peng1, Zhao Pengfei1
1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, P.R. China.
Background:
There have been recent efforts to characterize brain functional activity features in patients with pulsatile tinnitus (PT). These efforts have revealed evidence of aberrant functional connectivity (FC) of the right middle temporal gyrus (MTG) in PT patients with prolonged disease duration.
Purpose:
To assess the possible predictive effect of aberrant FC of MTG in PT patients with prolonged disease duration.
Study Type:
Retrospective.
Population:
Thirty-four patients with recent-onset PT (RPTIN), 24 patients with long-term PT (LPTIN), and 35 age-, gender-, and education-matched healthy controls were enrolled.
Field Strength/Sequence:
3.0T MRI system and echo-planar imaging (EPI) sequence, 3D brain volume imaging (BRAVO) sequence.
Assessment:
Functional MRI data preprocessing was performed in Data Processing & Analysis for Brain Imaging (DPABI) and Statistical Parametric Mapping (SPM) 8. The FC analyses were conducted using the software REST.
Statistical Tests:
One-way analysis of covariance was conducted between three groups with age and gender as covariates, and post-hoc analysis was used to identify the sources of group effects. Pearson's correlation analysis was conducted for the z-values of altered FC strength in the PT group and the clinical data.
Results:
Among hubs belonging to the executive control network, the default mode network (DMN), and limbic network, the strength of FC was mainly decreased in the patient groups compared with normal controls (P < 0.05). Relative to RPTIN patients and normal controls, LPTIN patients were further characterized by significantly decreased FC between several short-range brain regions adjacent to the seed (P < 0.05). Finally, disease duration was negatively correlated with decreased FC between the seed and right fusiform gyrus/parahippocampal gyrus, right inferior frontal gyrus, and right MTG (a brain area adjacent to the seed region).
Data Conclusion:
Long-term reactions to PT mainly involved weakened short-range FC, especially within a functional network in the right temporal lobe.
Level Of Evidence:
4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
More Related Videos
Related Concept Videos
01:05Long-term Depression
01:17Functions of Connective Tissues
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
02:26Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
01:25Network Function of a Circuit
01:26Bone Markings
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
00:59Range
15.9; 16.1; 15.2; 14.8; 15.8; 15.9; 16.0; 15.5
Measurements of the amount of soda in a 16-ounce can vary since different subjects record these measurements or since the exact amount - 16 ounces of liquid, was not...