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Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice

Dalong Ni1, Dawei Jiang1,2, Christopher J Kutyreff1

  • 1Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, 53705, USA.

Nature Communications
|December 22, 2018
PubMed

Insights

Novel molybdenum-based nanoclusters act as potent nano-antioxidants, effectively protecting against acute kidney injury (AKI) by scavenging reactive oxygen species (ROS) in preclinical models.

Area of Science:

  • Nanotechnology
  • Renal Medicine
  • Biochemistry

Background:

  • Acute kidney injury (AKI) is a significant cause of mortality, often linked to oxidative stress from reactive oxygen species (ROS).
  • Current AKI treatments are primarily supportive, highlighting the need for novel therapeutic agents that target ROS accumulation in the kidneys.

Purpose of the Study:

  • To develop and evaluate molybdenum-based polyoxometalate (POM) nanoclusters as targeted nano-antioxidants for the prevention and treatment of AKI.
  • To investigate the ROS-scavenging capabilities and renal accumulation of these novel POM nanoclusters.

Main Methods:

  • Synthesis of molybdenum-based polyoxometalate (POM) nanoclusters with inherent ROS-scavenging properties.
  • Evaluation of renal uptake and biodistribution using dynamic positron emission tomography (PET) imaging with 68Ga-EDTA.
  • Assessment of therapeutic efficacy in a mouse model of AKI through serum analysis, kidney tissue staining, and biomarker detection.

Main Results:

  • POM nanoclusters demonstrated preferential accumulation in the kidneys.
  • The nanoclusters effectively scavenged detrimental reactive oxygen species (ROS).
  • Significant alleviation of AKI symptoms was observed in mice treated with POM nanoclusters, confirmed by various physiological and histological assessments.

Conclusions:

  • Molybdenum-based POM nanoclusters show promise as effective nano-antioxidants for kidney protection against AKI.
  • These findings support further investigation into POM nanoclusters for treating AKI and other ROS-related diseases in clinical settings.

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