Related Experiment Video
Updated: Jan 31, 2026
08:44
Isolating Potentiated Hsp104 Variants Using Yeast Proteinopathy Models
Published on: November 11, 2014
8.5K
Variant Presentations of the Exstrophy-Epispadias Complex: A 40-Year Experience
Mahir Maruf1, Karl Benz1, John Jayman1
1Robert D. Jeffs Division of Pediatric Urology, Charlotte Bloomberg Children's Center, James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, MD.
Urology
|December 22, 2018
Summary
Variant exstrophy-epispadias complex (EEC) requires accurate diagnosis for effective management. Surgical reconstruction, particularly primary bladder closure, yields high success rates and good continence outcomes, comparable to typical EEC cases.
Area of Science:
- Pediatric Urology
- Congenital Abnormalities
- Surgical Reconstruction
Background:
- Variant presentations of the exstrophy-epispadias complex (EEC) are rare and diverse, posing diagnostic and management challenges.
- Understanding these variants is crucial for optimizing patient care and outcomes.
Purpose of the Study:
- To investigate the diagnosis, surgical management, and outcomes of patients with variant exstrophy-epispadias complex (EEC).
Main Methods:
- A review of an institutional database (1975-2018) identified 1336 EEC patients, focusing on variant presentations.
- Variant types included skin-covered bladder exstrophy (BE), duplicate bladders, superior vesical fistula, and epispadias with major bladder prolapse.
- Surgical management and outcomes were assessed for 44 identified EEC variants.
Main Results:
- The most common variant was skin-covered BE (43%).
- Eighty-two percent of variants underwent primary bladder closure, with 58% also receiving pelvic osteotomy; 89% of closures were successful.
- Continence procedures were performed in 17 patients, with 8 achieving continence and volitional voiding even without such procedures.
Conclusions:
- Skin-covered bladder exstrophy is the most frequent EEC variant.
- Accurate initial diagnosis is vital for timely and appropriate management of EEC variants.
- Successful surgical reconstruction of EEC variants can lead to continence rates similar to or better than non-variant EEC.
Related Concept Videos
01:25Self-Presentation
322
Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
322
02:05Self-Presentation: Self-Monitoring and Self-Handicapping
44.7K
People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
44.7K
01:12Strategies of Self-Presentation I: Strategic Self-Presentation
217
Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
217
01:29Processes of Self-Presentation
249
Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
249
02:30Histone Variants at the Centromere
5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
01:57Protein Complexes with Interchangeable Parts
2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K