Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients

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M A Karsdal1, K M Verburg2, C R West2

  • 1Nordic Bioscience, Herlev Hovedgade, DK-2730 Herlev, Denmark.

Osteoarthritis and Cartilage
|December 22, 2018
PubMed

Insights

Biomarkers can predict rapidly progressive osteoarthritis (RPOA) in osteoarthritis (OA) patients treated with tanezumab. This study identified specific biomarker combinations to identify patients at risk of RPOA type-2.

Area of Science:

  • Biochemistry
  • Orthopedics
  • Pharmacology

Background:

  • Osteoarthritis (OA) requires effective and safe pain management.
  • Tanezumab, a nerve growth factor (NGF) antibody, shows high efficacy but carries a risk of rapidly progressive osteoarthritis (RPOA) when combined with chronic NSAID use.
  • Identifying OA patients at risk for RPOA is crucial for safe treatment.

Purpose of the Study:

  • To identify biochemical biomarkers predicting RPOA type-2 in OA patients.
  • To phenotype OA patients at risk for RPOA type-2, considering both limited and chronic NSAID users.
  • To develop predictive models for RPOA type-2 risk.

Main Methods:

  • Analyzed biomarker data from OA patients in tanezumab trials, categorized by NSAID usage (limited <90 days, chronic ≥90 days).
  • Utilized 47 RPOA type-2 cases and 92 controls.
  • Developed non-linear and linear multivariable predictive models.

Main Results:

  • In limited NSAID users, two baseline biomarkers predicted RPOA type-2 with 71% ROC AUC, showing an 8-fold increased relative risk.
  • In chronic NSAID users, five biomarkers predicted RPOA type-2 with 78% AUC, indicating a 4-fold increased relative risk.
  • Identified specific biomarker combinations associated with RPOA type-2 development.

Conclusions:

  • Biomarker combinations can identify OA patients at risk for RPOA type-2.
  • These findings may elucidate the underlying pathology of RPOA type-2.
  • This exploratory study provides a basis for future research into RPOA prevention and management.
Keywords:
BiomarkerClinical studyOsteoarthritisRPOA2THR

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