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Cytotoxic limonoids from the bark of Walsura cochinchinensis

Binh T D Trinh¹, Hiep D Nguyen², Hieu T Nguyen¹

¹Faculty of Chemistry, University of Science, VNU-HCM, 227 Nguyen Van Cu, Ho Chi Minh City, Viet Nam.

|December 22, 2018

Abstract:

Three new limonoids, walsucochinones A-C (1-3), along with eight known compounds, were isolated from an ethyl acetate extract of the bark of Walsura cochinchinensis. Their structures were determined using spectroscopic techniques, mainly 1-D and 2-D NMR. The ethyl acetate extract showed cytotoxic activity against MCF-7 human breast cancer cells and cytotoxicity of the isolated compounds were evaluated in vitro using the SRB assay. Walsucochinone C (3) exhibited the most active effect with IC₅₀ value of 16.4 ± 0.2 μM.

Keywords:

Cytotoxicity Limonoids Meliaceae Phenolics Walsura cochinchinensis

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