Related Experiment Video

Updated: Jan 31, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

20.6K

Obstructive sleep apnea is associated with nonsustained ventricular tachycardia in patients with hypertrophic

Shengwei Wang1, Hao Cui2, Changpeng Song3

  • 1Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Heart Rhythm
|December 22, 2018
PubMed

Insights

Obstructive sleep apnea (OSA) is common in hypertrophic obstructive cardiomyopathy (HOCM) and linked to nonsustained ventricular tachycardia (NSVT). OSA severity correlates with NSVT risk, a marker for sudden cardiac death.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) increases risk of arrhythmias and sudden cardiac death.
  • Obstructive sleep apnea (OSA) is prevalent in HCM patients and linked to atrial fibrillation.

Purpose of the Study:

  • To investigate the association between nonsustained ventricular tachycardia (NSVT) and OSA in patients with hypertrophic obstructive cardiomyopathy (HOCM).

Main Methods:

  • 130 HOCM patients underwent polysomnography and Holter ECG.
  • Data analyzed for correlation between OSA severity and NSVT prevalence.

Main Results:

  • 55% of patients had OSA; 21% had NSVT.
  • NSVT prevalence increased significantly with OSA severity (P < .001).
  • Apnea-hypopnea index and family history of HCM/SCD were independent predictors of NSVT.

Conclusions:

  • OSA presence and severity are independently associated with NSVT in HOCM patients.
  • NSVT is a significant risk factor for adverse cardiovascular events in this population.
Abstract

Keywords:
Hypertrophic cardiomyopathyHypertrophic obstructive cardiomyopathyNonsustained ventricular tachycardiaObstructive sleep apneaSupraventricular tachycardiaVentricular arrhythmias

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

14.0K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
488
Sleep Apnea01:21

Sleep Apnea

Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
555
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.5K
Design Example: Measuring Distance Between Two Points with Obstructions01:10

Design Example: Measuring Distance Between Two Points with Obstructions

When measuring distances in areas with physical obstructions, such as a lake in a field, surveyors must employ techniques to calculate accurate lengths without direct line measurements. One effective method is the offset technique, which allows for precise distance estimation over inaccessible stretches.In this scenario, a surveyor must measure a side of an area that crosses a lake. Since the measuring tape cannot span the lake, the surveyor begins by establishing a baseline that aligns with...
398
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
4.5K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.7K