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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
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Cognitive impairment and drug responsiveness in mesial temporal lobe epilepsy

Sibel Celiker Uslu1, Burcu Yuksel2, Betul Tekin3

  • 1Samsun Training and Research Hospital Neurology Department, İlkadım, 55090 Samsun, Turkey.

Epilepsy & Behavior : E&B
|December 22, 2018
PubMed
Abstract

Insights

Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) patients show cognitive deficits. Increased seizure frequency in MTLE-HS significantly impairs verbal attention, alongside memory and frontal lobe functions.

Area of Science:

  • Neurology
  • Neuropsychology

Background:

  • Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most common epilepsy type, often resistant to antiepileptic drugs (AEDs).
  • Cognitive impairments, including memory deficits, are common in MTLE-HS, but effects on attention and executive functions require further investigation.

Purpose of the Study:

  • To investigate the relationship between clinical features and cognitive functions in MTLE-HS patients.
  • To compare cognitive performance between drug-responsive and pharmacoresistant MTLE-HS groups.

Main Methods:

  • Seventy-nine MTLE-HS patients (34 drug-responsive, 45 pharmacoresistant) and 30 healthy controls were assessed.
  • Cognitive tests evaluated attention, memory, and executive functions.

Main Results:

  • Both MTLE-HS groups performed worse than controls in memory and frontal lobe function tests.
  • The pharmacoresistant group exhibited significantly poorer attention test results compared to the drug-responsive group.

Conclusions:

  • Increased seizure frequency is a primary cause of verbal attention deficits in MTLE-HS.
  • Impaired memory and frontal lobe functions in MTLE-HS highlight the temporal lobe-prefrontal cortex connection.
Keywords:
Cognitive functionsDrug resistanceEpilepsyMesial temporal lobe epilepsyPrognosisTreatment

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