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Pharmacokinetic drug evaluation of abemaciclib for advanced breast cancer

Marie Robert1, Jean-Sébastien Frenel1, Emmanuelle Bourbouloux1

  • 1a Medical Oncology , Institut de Cancérologie de l'Ouest, René Gauducheau , St Herblain , France.

Expert Opinion on Drug Metabolism & Toxicology
|December 23, 2018
PubMed
Abstract

Insights

Abemaciclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor, improves progression-free survival in metastatic breast cancer. Further research is needed to identify biomarkers for patient selection and optimize combination therapies.

Area of Science:

  • Oncology
  • Pharmacology
  • Translational Medicine

Background:

  • Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors combined with endocrine therapy are a new standard for endocrine-receptor positive metastatic breast cancer.
  • Abemaciclib is an FDA-approved CDK4/6 inhibitor based on MONARCH1 and 2 trial results.

Purpose of the Study:

  • To review the preclinical and clinical development of abemaciclib in advanced breast cancer.
  • To describe current therapeutic indications and identify open questions regarding abemaciclib use.

Main Methods:

  • Review of preclinical data on abemaciclib.
  • Analysis of clinical trial results (MONARCH1 and 2) for abemaciclib in advanced breast cancer.

Main Results:

  • Phase III trials show abemaciclib significantly improves progression-free survival in metastatic breast cancer.
  • Abemaciclib demonstrates a manageable toxicity profile in patients.

Conclusions:

  • Abemaciclib offers a safe and effective treatment option for advanced breast cancer.
  • Identifying predictive biomarkers and exploring combination therapies are crucial for optimizing CDK4/6 inhibitor treatment.
Keywords:
CDK4/6 inhibitorsMetastatic breast cancerabemaciclibcell-cycle regulation

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