Related Experiment Video

Updated: Jan 31, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

Osthole inhibits triple negative breast cancer cells by suppressing STAT3

Xuanxuan Dai1,2, Changtian Yin1,2, Yi Zhang3

  • 1Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

Journal of Experimental & Clinical Cancer Research : CR
|December 23, 2018
PubMed
Abstract

Insights

Osthole, a natural compound, effectively inhibits triple-negative breast cancer (TNBC) growth and induces cell death by targeting STAT3. This suggests osthole as a promising therapeutic for TNBC management.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis due to lack of targeted therapies.
  • There is a critical need for novel therapeutic strategies against TNBC.
  • Osthole, a natural product, has shown anticancer potential, but its mechanism in TNBC is unknown.

Purpose of the Study:

  • To investigate the therapeutic potential of osthole against TNBC.
  • To elucidate the mechanism of action of osthole in TNBC.
  • To identify the molecular targets of osthole in TNBC.

Main Methods:

  • Investigated osthole's effects on cultured TNBC cells and a TNBC xenograft mouse model.
  • Employed high-throughput proteomics to identify osthole's direct binding protein.
  • Utilized STAT3 overexpression to assess its role in osthole's efficacy.

Main Results:

  • Osthole demonstrated significant inhibition of TNBC cell proliferation and induced apoptosis in vitro and in vivo.
  • Signal transducer and activator of transcription 3 (STAT3) was identified as a direct binding protein of osthole.
  • Osthole suppressed STAT3 activity, leading to reduced TNBC growth and apoptosis; STAT3 overexpression diminished osthole's effectiveness.

Conclusions:

  • Osthole exhibits potential as a novel therapeutic agent for triple-negative breast cancer.
  • Targeting STAT3 with osthole presents a promising strategy for developing new anti-TNBC drugs.
Keywords:
Cell apoptosisOstholeSTAT3Triple-negative breast cancerXenografts

More Related Videos

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells13:38

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

Published on: January 18, 2017

12.7K
Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

10.8K

Related Concept Videos

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K
Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
57.1K
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K
Positive, Negative, and Zero Work00:58

Positive, Negative, and Zero Work

Work is done on an object when energy is transferred to the object. In other words, work is done when a force acts on a body that undergoes a displacement from one position to another. By definition, the work done by a force is the integral of the force with respect to the displacement along its path. Forces can vary as a function of position, and displacements can occur along various paths between two points. The magnitude of a force multiplied by the cosine of the angle that the force makes...
22.2K
Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
92.4K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
560