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Updated: Jan 31, 2026

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
Published on: July 28, 2023
Emerging evidence linking the gut microbiome to neurologic disorders
Jessica A Griffiths1, Sarkis K Mazmanian2
1Division of Biology and Biological Engineering, California Institute of Technology, East California Boulevard, Pasadena, CA, 91125, USA. jgriffit@caltech.edu.
Abstract:
The gut microbiome contributes to the development and function of the immune, metabolic, and nervous systems. Furthermore, commensal bacteria modulate symptoms and pathology in mouse models of neuropsychiatric and neurodevelopmental diseases. Uncovering mechanisms that are utilized by the microbiome to mediate gut-brain connections may provide novel opportunities to target therapies to the gut in order to treat neurologic disorders.
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