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Related Concept Videos

Initiation of Translation02:33

Initiation of Translation

39.0K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.0K
Initiation of Translation02:33

Initiation of Translation

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8.1K
Translation01:31

Translation

156.4K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
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Translation01:31

Translation

17.8K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
17.8K
Termination of Translation01:44

Termination of Translation

27.7K
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
27.7K
Relative Risk01:12

Relative Risk

2.1K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
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Analysis of Translation Initiation During Stress Conditions by Polysome Profiling
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Translating Risk of Consumer-Initiated Genetic Testing.

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  • 1Department of Pathology, Emory School of Medicine, Atlanta, Georgia (Editor-in-Chief).

The Journal of Molecular Diagnostics : JMD
|December 23, 2018
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Summary
This summary is machine-generated.

This editorial reviews a new framework for assessing elective genomic testing. It provides guidance for the responsible use of these advanced genetic diagnostic tools.

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Area of Science:

  • Genomic Medicine
  • Clinical Genetics

Background:

  • Elective genomic testing is increasingly accessible.
  • A standardized framework is needed for its evaluation.

Discussion:

  • The article by Bick and colleagues proposes a novel framework.
  • This framework aids in assessing the utility and validity of genomic tests.

Key Insights:

  • Highlights the importance of a structured approach to genomic test evaluation.
  • Emphasizes the need for clinical utility and ethical considerations.

Outlook:

  • Potential to guide clinical practice and policy development.
  • Facilitates informed decision-making for patients and healthcare providers.