Related Experiment Video
Updated: Jan 31, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Poor peer relations in adolescence, social support in early adulthood, and depressive symptoms in later
Christopher G Bean1, Ronnie Pingel1, Johan Hallqvist1
1Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Purpose:
Supportive social relations are associated with good mental health, yet few studies have considered the prospective importance of adolescent peer relations for adult mental health and the potential mechanisms involved.
Methods:
Participants (n = 941) were sourced from the Northern Swedish Cohort, a prospective study comprising school students aged 16 years in 1981. Integrating life course epidemiology with four-way decomposition analysis, this paper considers the controlled direct effect of poor peer relations at age 16 years on depressive symptoms at age 43 years, the pure indirect effect mediated by the availability of social support at age 30 years, and potential interactions between the exposure and the mediator.
Results:
After controlling for gender, baseline depressive symptoms, and parental socioeconomic position, poor peer relations at age 16 years were associated with depressive symptoms at age 43 years, largely irrespective of social support at age 30 years. Nonetheless, poor peer relations in adolescence were associated with poorer social support at age 30 years, and mediation accounted for a modest proportion (pure indirect effect 10%) of the association between poor peer relations at age 16 years and depressive symptoms at age 43 years.
Conclusions:
Policies to foster constructive peer relations for adolescents at school are encouraged; such policies may promote both the availability of social support and better mental health across the life course.
More Related Videos
07:15Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
Published on: March 15, 2024
11:13The Social Dimension of Stress: Experimental Manipulations of Social Support and Social Identity in the Trier Social Stress Test
Published on: November 19, 2015
Related Concept Videos
Theory of Romantic Attachment in Adulthood
Emerging Adulthood
Cognitive Development During Adulthood
Erikson's Theory on Socioemotional Development during Adulthood
Intimacy Versus Isolation in Early Adulthood
Individuals in early...
Piaget's Theory of Cognitive Development from Childhood into Adulthood
Schemata: Building Blocks of Knowledge
Synthesis and Decomposition Reactions