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Author Spotlight: Establishing a Murine Non-Small Cell Lung Cancer Model for Developing Nanoformulations of Anticancer Drugs
Published on: May 10, 2024
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Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for nonsmall cell lung cancer
Jun Lu1,2,3, Hua Zhong1,3, Tianqing Chu1
1Dept of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
The European Respiratory Journal
|December 23, 2018
Summary
Anlotinib prolongs survival in advanced non-small cell lung cancer (NSCLC) by inhibiting angiogenesis via CCL2. Decreased serum CCL2 levels may predict treatment response in NSCLC patients.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Anlotinib improves progression-free survival (PFS) and overall survival (OS) in refractory advanced non-small cell lung cancer (NSCLC).
- The molecular mechanisms and predictive biomarkers for anlotinib response remain unclear.
Purpose of the Study:
- To identify biomarkers predicting anlotinib response in NSCLC patients.
- To elucidate the anti-tumor molecular mechanisms of anlotinib.
Main Methods:
- Retrospective analysis of 294 NSCLC patients treated with anlotinib.
- Transcriptome and functional assays to investigate anti-tumor mechanisms.
- Analysis of serum CCL2 levels to correlate with treatment response.
Main Results:
- Anlotinib benefited NSCLC patients with driver gene mutations, particularly EGFRT790M.
- Anlotinib inhibited angiogenesis by suppressing CCL2 in a xenograft model.
- Decreased serum CCL2 levels correlated with improved PFS and OS.
Conclusions:
- Anlotinib exhibits anti-angiogenic activity by inhibiting CCL2.
- Serum CCL2 levels can potentially monitor and predict clinical outcomes in advanced NSCLC patients receiving anlotinib.
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