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Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy OCM
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Staging mouse preimplantation development in vivo using optical coherence microscopy.

Emma L Moore1, Shang Wang1, Irina V Larina1

  • 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas.

Journal of Biophotonics
|December 23, 2018
PubMed
Summary

Researchers developed an in vivo imaging method to observe mammalian preimplantation development within the oviduct. This optical coherence microscopy (OCM) technique allows detailed visualization of early embryos, advancing reproductive biology research.

Keywords:
in vivo imagingmouseoptical coherence microscopyoviductpreimplantation development

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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Biomedical Imaging

Background:

  • Preimplantation development in mammals occurs within the oviduct, but current studies use ex vivo methods, missing the native environment's influence.
  • Understanding the oviduct's role in early embryonic health and development is limited by the lack of in vivo observation techniques.

Purpose of the Study:

  • To develop and demonstrate an in vivo optical imaging approach for visualizing mammalian preimplantation embryos within the oviduct.
  • To enable high-resolution, real-time observation of early embryonic development in its natural biological setting.

Main Methods:

  • Combined optical coherence microscopy (OCM) with a dorsal imaging window for in vivo visualization.
  • Utilized the mouse model for its established genetic engineering capabilities and relevance to mammalian reproduction.
  • Collected high-resolution images of oocytes, zygotes, and preimplantation embryos, comparing OCM with bright-field microscopy.

Main Results:

  • Achieved high-resolution, in vivo visualization of subcellular structures and morphologies of developing embryos in the mouse oviduct.
  • Successfully staged embryonic development based on in vivo OCM imaging.
  • Demonstrated comparable imaging quality between in vivo OCM and traditional bright-field microscopy.

Conclusions:

  • The developed in vivo OCM approach provides unprecedented insights into mammalian preimplantation development within the oviduct.
  • This technique opens avenues for investigating oviduct-embryo interactions crucial for successful implantation.
  • Potential applications include advancing understanding of infertility and improving in vitro fertilization (IVF) outcomes.