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The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
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Updated: Jan 31, 2026

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
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Double-Stranded RNA Sensing Determines Epithelial Cell Identity.

Chung-Ping Liao1, Edem Tchegnon2, Lu Q Le3

  • 1Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

The Journal of Investigative Dermatology
|December 24, 2018
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Summary
This summary is machine-generated.

Researchers identified Keratin 9 as a key marker for volar skin keratinocytes. Its expression is linked to the double-stranded RNA receptor DDX58, offering potential ways to control skin thickness and durability.

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Area of Science:

  • Dermatology
  • Molecular Biology
  • Genomics

Background:

  • Skin epithelium comprises diverse keratinocytes across body regions.
  • Understanding site-specific epidermal cell identity is crucial for skin biology.

Purpose of the Study:

  • To investigate site-specific epidermal cell identity on volar skin using transcriptome analysis.
  • To identify key molecular markers and pathways involved in volar skin characteristics.

Main Methods:

  • Transcriptome analysis of epidermal cells from volar skin.
  • Gene expression profiling to identify differentially expressed genes.
  • Correlation analysis between gene expression and skin characteristics.

Main Results:

  • Keratin 9 is highly enriched in volar keratinocytes.
  • Keratin 9 expression is dependent on low expression of the double-stranded RNA receptor DDX58.
  • DDX58's role suggests double-stranded RNA sensing as a potential target.

Conclusions:

  • Keratin 9 serves as a specific marker for volar skin keratinocytes.
  • The DDX58 pathway offers a potential mechanism for modulating skin thickness and durability.
  • Targeting double-stranded RNA sensing pathways could be a novel therapeutic approach for skin conditions.