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Cough and the common cold.

F J Curley1, R S Irwin, M R Pratter

  • 1Division of Pulmonary Medicine, University of Massachusetts Medical School, Worcester 01655.

The American Review of Respiratory Disease
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

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Common cold cough stems from upper respiratory irritation. Antihistamine-decongestant treatment effectively reduces cough and other cold symptoms like postnasal drip and nasal congestion.

Area of Science:

  • Medicine
  • Pharmacology

Background:

  • The common cold is a frequent ailment with cough being a primary symptom.
  • The exact cause of cough in common colds and the efficacy of antihistamine-decongestant therapy remain areas of investigation.

Purpose of the Study:

  • To investigate if cough in the common cold originates from upper respiratory stimuli.
  • To evaluate the effectiveness of antihistamine-decongestant therapy in treating cold-induced cough.

Main Methods:

  • A randomized, double-blind, placebo-controlled study involving volunteers with common colds.
  • Participants completed questionnaires, underwent physical examinations, throat culturing, and pulmonary function tests.
  • Symptom severity was tracked daily for 14 days using diaries, with repeated pulmonary function tests.

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Main Results:

  • Cough severity was significantly correlated with throat-clearing and postnasal drip.
  • Antihistamine-decongestant therapy reduced postnasal drip, nasal obstruction, nasal discharge, and throat-clearing.
  • Cough prevalence decreased by 20-30% within 3 days in the active treatment group.

Conclusions:

  • The cough associated with the common cold is primarily caused by upper respiratory tract stimuli.
  • Antihistamine-decongestant therapy effectively alleviates cough and other major symptoms of the common cold, particularly when symptoms are most severe.