Related Experiment Video

Updated: Jan 31, 2026

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
09:03

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

Published on: November 17, 2014

10.1K

Fungal infections in solid organ transplantation: An update on diagnosis and treatment

Vincent Kabir1, Johan Maertens2, Dirk Kuypers3

  • 1KU Leuven, Leuven, Herestraat 49, 3000 Leuven, Belgium.

Transplantation Reviews (Orlando, Fla.)
|December 24, 2018
PubMed

Insights

Invasive fungal infections are a major threat to solid organ transplant recipients, with diagnosis and management remaining challenging. This review focuses on improving outcomes through better understanding of risk factors, diagnosis, and management strategies for these infections.

Area of Science:

  • Transplantation Medicine
  • Mycology
  • Infectious Diseases

Background:

  • Invasive fungal infections (IFIs) are a significant cause of morbidity and mortality in solid organ transplantation (SOT) recipients.
  • Effective management of IFIs is crucial for patient outcomes, yet diagnosis and treatment are complicated by varied symptoms and limited diagnostic tools.

Purpose of the Study:

  • To review current evidence on risk factors, clinical manifestations, and timing of IFIs in SOT recipients.
  • To focus on the diagnosis and management of IFIs, emphasizing the role of fungal biomarkers.

Main Methods:

  • Literature review of current evidence regarding IFIs in SOT.
  • Analysis of diagnostic and management strategies, including prophylactic approaches and antifungal susceptibility testing.

Main Results:

  • Fungal biomarkers show promise for increasing diagnostic accuracy and improving clinical outcomes.
  • Optimal prophylactic strategies remain inconclusive, leading to varied clinical practices.
  • Antifungal use increases costs and resistance risk, complicating treatment protocols.

Conclusions:

  • Improved diagnostic accuracy through biomarkers is essential for better management of IFIs in SOT.
  • Standardized protocols for prophylaxis and treatment are needed, considering pathogen resistance and cost-effectiveness.
Keywords:
Fungal infectionsSolid organ transplantation

More Related Videos

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis06:23

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis

Published on: May 23, 2021

5.4K
Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules10:26

Author Spotlight: A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules

Published on: May 19, 2023

2.5K

Related Concept Videos

Metallic Solids02:37

Metallic Solids

Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
Structures of Solids02:22

Structures of Solids

Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K
Network Covalent Solids02:18

Network Covalent Solids

Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
1.3K
Nursing Diagnosis01:22

Nursing Diagnosis

Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
4.1K