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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
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Clinical Features and Prognostic Factors in Elderly Ewing Sarcoma Patients
Hua-Fei Liu1,2, Ji-Xin Wang3, Dong-Quan Zhang3
1Department of Orthopaedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).
Summary
Elderly patients with Ewing sarcoma face poor prognoses. Combining surgery and chemotherapy significantly improves survival outcomes for this patient group.
Area of Science:
- Oncology
- Geriatric Medicine
- Cancer Research
Background:
- Elderly patients with Ewing sarcoma exhibit a very poor prognosis.
- Treatment challenges and prognostic factors for elderly Ewing sarcoma patients are under-documented.
Purpose of the Study:
- To investigate the prognosis of elderly Ewing sarcoma patients.
- To determine independent prognostic factors in this specific cohort.
Main Methods:
- Utilized the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database.
- Identified Ewing sarcoma patients aged over 40 years (1973-2015).
- Employed Kaplan-Meier method and Cox proportional hazard regression for prognostic analysis.
Main Results:
- Included 162 elderly patients (mean age 53 years).
- Achieved 5-year overall survival (OS) and cancer-specific survival (CSS) rates of 43.7% and 47.9%.
- Multivariable analysis identified tumor stage, surgery, and chemotherapy as significant indicators for OS and CSS.
Conclusions:
- Surgery combined with chemotherapy demonstrated a significant survival benefit.
- This combined treatment approach is recommended for elderly Ewing sarcoma patients.
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