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Two highly oxygenated Ergosterols from cultures of the Basidiomycete Conocybe siliginea
Chao-Jun Pu1, Yue-Ling Peng1, Zheng-Hui Li1
1School of Pharmaceutical Sciences, South-Central University for Nationalities , Wuhan , China.
Abstract:
Two highly oxygenated ergosterols, (22E,24R)-3β,5α,6β,9α,14α,25-hexhydroxyergosta-7,22-diene (1), and (22E,24R)-3β,5α,6β,14α,25-pentahydroxyergosta-7,9(11),22-triene (2), together with two known ones, have been isolated from cultures of the basidiomycete Conocybe siliginea. Their structures were elucidated on the basis of extensive spectroscopic means. Two new compounds (1 and 2) were tested for their nitric oxide synthase inhibitory activities. However, none of them showed any activity (IC50 > 40 μM).
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