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Related Experiment Videos

Methylphenidate and growth in hyperactive children. A controlled withdrawal study.

R G Klein1, B Landa, J A Mattes

  • 1Long Island Jewish Medical Center, Hillside Division, Glen Oaks, NY.

Archives of General Psychiatry
|December 1, 1988
PubMed
Summary

Methylphenidate hydrochloride, a stimulant, may impact growth in hyperactive children. Stopping treatment for two summers improved height, but not weight, suggesting a link between medication exposure and reduced growth velocity.

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Area of Science:

  • Pediatric endocrinology
  • Neurodevelopmental disorders
  • Pharmacology

Background:

  • The impact of stimulant medications on growth in children with attention deficit hyperactivity disorder (ADHD) remains a subject of debate.
  • Methylphenidate hydrochloride is a commonly prescribed stimulant for ADHD.

Purpose of the Study:

  • To investigate the effects of methylphenidate withdrawal on the growth of hyperactive children over two consecutive summers.
  • To determine if discontinuing methylphenidate treatment influences height and weight velocity.

Main Methods:

  • A randomized controlled trial was conducted with hyperactive children on long-term methylphenidate hydrochloride treatment.
  • Participants were randomly assigned to either discontinue or continue their medication regimen over two summer periods.

Related Experiment Videos

  • Height and weight were measured to assess growth parameters.

    • Main Results:

    • After one summer, no significant difference in height was observed between groups, but weight was higher in the group that stopped methylphenidate.
    • Discontinuing methylphenidate treatment for two consecutive summers resulted in a significant positive effect on height, with no significant impact on weight.
    • These findings indicate a correlation between methylphenidate exposure and diminished growth velocity.

    Conclusions:

    • Methylphenidate withdrawal for two summers positively influenced height in hyperactive children.
    • The study suggests a direct relationship between methylphenidate exposure and reduced growth velocity.
    • Further research is needed to ascertain the long-term effects of methylphenidate on final adult height.