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Updated: Jan 31, 2026

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
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Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models

Aishwarya G Nadadhur1, Mouhamed Alsaqati2, Lisa Gasparotto3

  • 1Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, the Netherlands.

Stem Cell Reports
|December 25, 2018
PubMed
Summary

Tuberous sclerosis complex (TSC) patient cells reveal neuron-glia interactions worsen brain defects. Rapamycin treatment reversed these cellular abnormalities, offering a new model for TSC drug development.

Keywords:
autismco-culturegliaiPSCin vitro modelmyelinneuronneuronal activityoligodendrocytetuberous sclerosis complex

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