Related Experiment Video
Updated: Jan 31, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
Role of Methadone in Extracorporeal Membrane Oxygenation: Two Case Reports
Erik Dong1, Robert Fellin1, Danny Ramzy1
1Cedars Sinai Medical Center, Los Angeles, California.
Abstract:
Extracorporeal membrane oxygenation (ECMO) affects pharmacokinetics/dynamics of drugs in unpredictable ways. Anecdotally, ECMO patients require high doses of opioids and sedatives, leading to concerns of tolerance. Methadone is a long-acting synthetic opioid with antagonist properties at the n-methyl-d-aspartate (NMDA) receptor. It has been shown to improve spontaneous breathing trials and weaning from mechanical ventilation; however, there is no literature describing its use in ECMO. We describe two patients from the cardiac surgery intensive care unit at Cedars Sinai (Los Angeles, CA) on ECMO for over 30 days maintained on methadone.
More Related Videos
Related Concept Videos
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Data Reporting and Recording
Introduction to Membrane Proteins
Types of Reports I: Hands-off Report
Following are the key components and categories of hand-off reports:
Purpose and Process:
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...

