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Relationship between response to lusutrombopag and splenic volume

Haruki Uojima1, Yoshitaka Arase2, Norio Itokawa3

  • 1Department of Gastroenterology, Shonan Kamakura General Hospital, Kamakura 247-8533, Japan.

World Journal of Gastroenterology
|December 25, 2018
PubMed

Insights

Splenic volume impacts lusutrombopag efficacy in chronic liver disease patients. Lower splenic volume correlated with increased platelet counts, suggesting it

Area of Science:

  • Hepatology
  • Hematology
  • Pharmacology

Background:

  • Chronic liver disease (CLD) frequently leads to thrombocytopenia, increasing bleeding risk.
  • Lusutrombopag is a thrombopoietin receptor agonist used to increase platelet counts.
  • Predictors of lusutrombopag response in CLD patients require further investigation.

Purpose of the Study:

  • To evaluate the correlation between lusutrombopag efficacy and patient clinical characteristics.
  • To identify factors influencing treatment response in thrombocytopenic CLD patients.

Main Methods:

  • Retrospective, multicenter study of 50 thrombocytopenic CLD patients in Japan.
  • Patients received oral lusutrombopag (3.0 mg/day for 7 days).
  • Treatment response defined by specific platelet count increases post-administration.

Main Results:

  • 80% of patients responded to lusutrombopag.
  • Responders had significantly lower splenic volume and body weight compared to non-responders.
  • Higher white blood cell count and hemoglobin levels were observed in responders.
  • Multivariate analysis identified splenic volume as an independent predictor of response (OR=11.2, P=0.025).
  • Splenic volume negatively correlated with changes in platelet count (r=-0.524, P=0.001).

Conclusions:

  • Splenic volume is a key factor influencing platelet count changes after lusutrombopag administration in CLD patients.
  • This finding may aid in predicting treatment outcomes and optimizing therapy.
Abstract

Keywords:
LusutrombopagPortal hypertensionSplenic volumeThrombocytopeniaThrombopoietin receptor agonist

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