Related Experiment Video
Updated: Jan 31, 2026
11:05
Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
38.2K
Association Between Oxidative Stress and Melanoma Progression
Jelena Pantic Bisevac1, Mirjana Djukic2, Ivan Stanojevic3,4
1Institute of Medical Biochemistry, Military Medical Academy, Belgrade, Serbia.
Journal of Medical Biochemistry
|December 25, 2018
Summary
Melanoma is linked to oxidative stress, with higher levels of damaging free radicals and malondialdehyde observed in patients. Antioxidant enzyme activity also changed with disease progression.
Area of Science:
- Biochemistry
- Oncology
- Dermatology
Background:
- Oxidative stress, an imbalance between free radicals and antioxidants, is implicated in cancer development.
- Malignant melanocyte transformation and melanoma progression are associated with impaired redox homeostasis.
Purpose of the Study:
- To investigate the association between oxidative stress markers and different stages of melanoma.
- To evaluate redox hemostasis in melanoma patients compared to healthy controls.
Main Methods:
- Spectrophotometric measurement of superoxide anion radical, malondialdehyde, total and manganese superoxide dismutase, and catalase.
- Analysis of serum samples from 72 melanoma patients and 30 healthy controls, stratified by AJCC clinical stage.
Main Results:
- Melanoma patients exhibited significantly higher superoxide anion and malondialdehyde levels than controls.
- Superoxide anion peaked in stage III, while malondialdehyde peaked in stage IV.
- Catalase activity increased with melanoma progression, peaking in stage III, and manganese superoxide dismutase activity was highest in stage IV.
Conclusions:
- Melanoma is strongly associated with oxidative stress.
- Deteriorated cellular function at the mitochondrial level is suggested in melanoma patients.
Related Concept Videos
03:14Oxidation Numbers
42.6K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.6K
01:15Pyruvate Oxidation
168.8K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
168.8K
01:21Association Areas of the Cortex
9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
01:27Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
03:11Oxidation-Reduction Reactions
75.7K
Oxidation–Reduction Reactions
75.7K
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K