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Pattern and Frequency of Short Stature in Albanian Children
A Gjikopulli1, L Grimci1, L Kollcaku1
1Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Centre "Mother Teresa", Albania.
Insights
A study in Albania found that 46% of children with short stature had an underlying medical condition. Early growth monitoring is crucial for timely diagnosis and intervention in pediatric short stature.
Area of Science:
- Pediatric Endocrinology
- Growth and Development
- Medical Diagnostics
Background:
- Short stature is defined as height more than 2 standard deviations below the mean for age and sex.
- While numerous medical conditions can cause poor growth, most short children are otherwise healthy.
- Identifying the cause of short stature is essential for appropriate management.
Purpose of the Study:
- To identify and analyze the causes of short stature in Albanian children.
- To evaluate factors contributing to growth failure in a pediatric population.
Main Methods:
- Study included 564 children with short stature or slow growth velocity (<-2 z-score).
- Evaluations involved anthropometric measurements, biochemical and hormonal analyses, radiological studies, and provocative tests.
- Statistical analysis was performed using Epi-Info CDC 2000 and SPSS.
Main Results:
- The study analyzed 564 children aged 0.65-18.74 years.
- Constitutional short stature (37.4%) and growth hormone (GH) deficit (27.5%) were the most frequent diagnoses.
- Other diagnoses included genetic syndromes (11.9%), familial short stature (6.7%), and idiopathic short stature (5.5%).
Conclusions:
- A significant proportion (46%) of children evaluated had a pathological cause for their growth failure.
- This highlights the necessity for vigilant growth monitoring and prompt specialist referral.
- Delayed evaluation suggests suboptimal growth surveillance in Albania.
Introduction:
Short stature is defined as a standing height more than 2 standard deviations (SDs) below the mean for age and sex. While there are many medical causes for being short and having poor growth, including growth hormone deficiency, hypothyroidism, Turner syndrome, inflammatory bowel disease, kidney problems, malnutrition, etc., most children who are short are normal.
Objectives:
The identification and analysis of causes and factors leading to short stature in Albanian children.
Patients & Methods:
Subjects enrolled in our study were admission with "Short stature" or "Slow growth velocity" from January 2001 to January 2011 and met the criteria: length < -2 z- score and/or height velocity <-2 z- score for age and sex. They were evaluated by anthropometric measurements; biochemical panel; hormonal balance; radiological studies; and hormonal provocative tests. Statistical processing was done with Epi-Info CDC 2000 and SPSS accordingly.
Results:
The age of the 564 children was from 0.65-18.74 years (11.08 ± 3.28 years).
M / F:
221/343 (39% /61%) respectively. The frequency of diagnoses resulted as follows: the "constitutional short stature" 211children (37.4%), "GH deficit" 155(27.5%), "genetic syndrome" 67(11.9%), "familiar short stature" 38(6.7%), "others pathology" 38(6.7%), "idiopathic short stature" 31(5.5%), "i-uterine short stature" 16(2.8%).
Conclusions:
The fact that 46% of the explored children resulted positive in terms of a pathology that had caused primary or secondary growth failure, makes it necessity careful monitoring of growth and reference of the children to a specialist as fast as possible. Evidently great age of exploration indicates a weak surveillance on growth monitoring in Albania.
Recommendations:
Assessment of the child's growth must be a routine procedure. The early identification of stature growth delay will significantly increase the early detection of any pathology.
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