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Analysis of Early Stroke-induced Changes in Circulating Leukocyte Counts using Transcriptomic Deconvolution.

Grant C O'Connell1, Julia H C Chang1

  • 1School of Nursing, Case Western Reserve University, Cleveland, OH, USA.

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PubMed
Summary
This summary is machine-generated.

Stroke significantly alters circulating immune cells, decreasing lymphoid populations and increasing neutrophils and monocytes. Eosinophil counts notably decrease following stroke, offering new insights into stroke pathophysiology.

Keywords:
CBCComplete blood countEosinophilImmune suppressionInfectionNLRNeutrophil lymphocyte ratioWBCWBC DifferentialWhite blood cell

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Area of Science:

  • Immunology
  • Neurology
  • Computational Biology

Background:

  • Stroke is known to affect the peripheral immune system.
  • Understanding these changes is crucial for stroke pathophysiology insights.

Purpose of the Study:

  • To characterize early changes in circulating leukocyte populations after ischemic stroke.
  • To investigate the impact of stroke on immune cell phenotypes.

Main Methods:

  • Utilized transcriptomic deconvolution on whole blood mRNA expression data.
  • Analyzed microarray data from stroke patients and controls at 3, 5, and 24 hours post-symptom onset.
  • Validated findings in an independent patient cohort.

Main Results:

  • Stroke led to decreased inferred counts of B-cells, CD4+ T-cells, CD8+ T-cells, γδ T-cells, and NK-cells.
  • Stroke samples showed increased inferred counts of neutrophils and monocytes.
  • Significantly lower inferred counts of eosinophils and dendritic cells were observed in stroke patients, particularly at 5 and 24 hours.

Conclusions:

  • Stroke induces significant, time-dependent alterations in the circulating leukocyte pool.
  • The study provides evidence for an acute decrease in eosinophil counts post-stroke.
  • These findings enhance the understanding of early immune responses to stroke.